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Hemorphin-7

Names

[ CAS No. ]:
152685-85-3

[ Name ]:
Hemorphin-7

[Synonym ]:
L-Phenylalanine, L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-N5-(diaminomethylene)-L-ornithyl-
L-Phenylalanine, L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-
L-Tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-L-arginyl-L-phenylalanine
L-Tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-L-glutaminyl-N5-(diaminomethylene)-L-ornithyl-L-phenylalanine

Biological Activity

[Description]:

Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Cardiovascular Disease
Peptides

[References]

[1]. Dejouvencel T, et al. Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):269-75.


[Related Small Molecules]

Angiotensin I/II (1-7) trifluoroacetate salt | PZM-21 | Captopril | Loperamide hydrochloride | Enalapril maleate | Oliceridine hydrochloride | ADL5859 HCl | JDTic (dihydrochloride) | Naltrindole hydrochloride | Perindopril erbumine | LY-2456302 | JTC-801 | Lisinopril diydrate | Phosphoramidon disodium salt | Matrine

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C49H64N12O11

[ Molecular Weight ]:
997.106

[ Exact Mass ]:
996.481750

[ LogP ]:
1.11

[ Index of Refraction ]:
1.689

[ Storage condition ]:
2-8℃

Related Compounds

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