Ketoleucine

Names

[ CAS No. ]:
816-66-0

[ Name ]:
Ketoleucine

[Synonym ]:
2-Oxo-4-methylvaleric acid
α-ketoisocaproic acid
2-Oxoisocaproic acid
2-KETOISOCAPROIC ACID
EINECS 212-435-5
4-Methyl-2-oxopentanoic acid
Pentanoic acid, 4-methyl-2-oxo-
&α;-ketoisocaproic acid
2-keto-4-Methylvaleric acid
4-Methyl-2-oxovaleric Acid
4-methyl-2-oxo-Valeric acid
Ketoleucine
MFCD00066204
α-keto-isocaproic acid

Biological Activity

[Description]:

4-Methyl-2-oxopentanoic acid, an abnormal metabolite, is both a neurotoxin and a metabotoxin.

[Related Catalog]:

Natural Products >> Acids and Aldehydes

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Yudkoff M, et al. Brain amino acid requirements and toxicity: the example of leucine. J Nutr. 2005 Jun;135(6 Suppl):1531S-8S.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
190.5±9.0 °C at 760 mmHg

[ Melting Point ]:
8-10 °C

[ Molecular Formula ]:
C₆H₁₀O₃

[ Molecular Weight ]:
130.142

[ Flash Point ]:
83.3±15.2 °C

[ Exact Mass ]:
130.062988

[ PSA ]:
54.37000

[ LogP ]:
0.17

[ Vapour Pressure ]:
0.2±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.438

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

The signalling role of action potential depolarization in insulin secretion: metabolism-dependent dissociation between action potential increase and secretion increase by TEA.

Biochem. Pharmacol. 80(1) , 104-12, (2010)

The K(+) channel blocker, TEA is known to increase action potential amplitude and insulin secretion of mouse beta-cells when added to a nutrient secretagogue. In the presence of a maximally effective ...

Production of α-ketoisocaproate via free-whole-cell biotransformation byRhodococcus opacusDSM 43250 withl-leucine as the substrate

Enzyme Microb. Technol. 49(4) , 321-5, (2011)

This work aims to produce α-ketoisocaproate (KIC) from l-leucine via the free-whole-cell biotransformation of Rhodococcus opacus DSM 43250. The effects of temperature, pH, substrate concentration, cel...