ML 184

Names

[ Name ]:
ML 184

[Synonym ]:
MFCD06367291
Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-
3-{[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl}-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
CID2440433

Biological Activity

[Description]:

ML-184 (ML184) is a potent, selective GPR55 agonist with EC50 of 263 nM, >120-fold, 83-fold, and 57-fold selectivity against GPR35, CB1 and CB2; shows activity in activating the downstream responses of ERK phosphorylation and PKC β II translocation.

[References]

References 1. Heynen-Genel S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Lingerfelt MA, et al. Biochemistry. 2017 Jan 24;56(3):473-486. View Related Products by Target GPR55

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
681.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₄N₄O₃S

[ Molecular Weight ]:
470.628

[ Flash Point ]:
365.9±34.3 °C

[ Exact Mass ]:
470.235168

[ LogP ]:
2.29

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
-20°C

ML 184

Names

Biological Activity

Chemical & Physical Properties

Related Compounds