794572-10-4
794572-10-4 structure
- Name: ML 184
- Chemical Name: CID2440433
- CAS Number: 794572-10-4
- Molecular Formula: C25H34N4O3S
- Molecular Weight: 470.628
- Catalog: Signaling Pathways GPCR/G Protein GPR55
- Create Date: 2020-01-12 10:30:28
- Modify Date: 2024-01-06 17:55:28
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ML-184 (ML184) is a potent, selective GPR55 agonist with EC50 of 263 nM, >120-fold, 83-fold, and 57-fold selectivity against GPR35, CB1 and CB2; shows activity in activating the downstream responses of ERK phosphorylation and PKC β II translocation.
| Name | CID2440433 |
|---|---|
| Synonyms |
MFCD06367291
Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)- 3-{[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl}-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide CID2440433 |
| Description | ML-184 (ML184) is a potent, selective GPR55 agonist with EC50 of 263 nM, >120-fold, 83-fold, and 57-fold selectivity against GPR35, CB1 and CB2; shows activity in activating the downstream responses of ERK phosphorylation and PKC β II translocation. |
|---|---|
| References | References 1. Heynen-Genel S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Lingerfelt MA, et al. Biochemistry. 2017 Jan 24;56(3):473-486. View Related Products by Target GPR55 |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 681.4±65.0 °C at 760 mmHg |
| Molecular Formula | C25H34N4O3S |
| Molecular Weight | 470.628 |
| Flash Point | 365.9±34.3 °C |
| Exact Mass | 470.235168 |
| LogP | 2.29 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.607 |
| Storage condition | -20°C |