Diethylene glycol bis(p-toluenesulfonate)

Names

[ Name ]:
Diethylene glycol bis(p-toluenesulfonate)

[Synonym ]:
Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate)
Oxydi-2,1-ethanediyl bis(4-methylbenzenesulfonate)
oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate)
MFCD00026001
2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate

Biological Activity

[Description]:

Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
581.2±45.0 °C at 760 mmHg

[ Melting Point ]:
87-89 °C(lit.)

[ Molecular Formula ]:
C₁₈H₂₂O₇S₂

[ Molecular Weight ]:
414.493

[ Flash Point ]:
305.3±28.7 °C

[ Exact Mass ]:
414.080688

[ PSA ]:
112.73000

[ LogP ]:
2.70

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2904100000

Customs

[ HS Code ]: 2904100000

[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Synthesis of new benzosulfoxide macrocyclic compounds. Shockravi A, et al.

Phosphorus. Sulfur. Silicon Relat. Elem. 179(3) , 535-41, (2004)