Triethylene glycol bis(p-toluenesulfonate)

Names

[ CAS No. ]:
19249-03-7

[ Name ]:
Triethylene glycol bis(p-toluenesulfonate)

[Synonym ]:
Ethanol, 2,2'-(1,2-ethanediylbis(oxy))bis-, bis(4-methylbenzenesulfonate)
1,2-Ethanediylbis(oxy-2,1-ethanediyl) bis(4-methylbenzenesulfonate)
2-[2-(2-([(4-Methylphenyl)sulfonyl]oxy)ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate
TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE
ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Triethylene Glycol Bis(p-toluenesulfonate)
TsOCH2(CH2OCH2)2CH2OTs
Triethylene glycol di(p-toluenesulfonate)
Triethylene Glycol Di-p-tosylate
triethylene glycol bis(4-toluenesulfonate)
1,2-Bis(2-tosyloxyethoxy)ethane
Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate)
bis-tosylated triethyleneglycol
MFCD00048096
Triethylene glycol ditosylate
1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane
2,2'-(Ethylenedioxy)diethyl Ditosylate
(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
2-(2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfon ate
Tos-PEG4-Tos

Biological Activity

[Description]:

Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
608.4±55.0 °C at 760 mmHg

[ Melting Point ]:
78-82 °C(lit.)

[ Molecular Formula ]:
C₂₀H₂₆O₈S₂

[ Molecular Weight ]:
458.546

[ Flash Point ]:
321.7±31.5 °C

[ Exact Mass ]:
458.106903

[ PSA ]:
121.96000

[ LogP ]:
2.34

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.545

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909309090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

G.W. Gokel, S.H. Korzeniowski

Macrocyclic Polyether Synthesis , (1982)