PROTAC Linker 16

Names

[ Name ]:
PROTAC Linker 16

[Synonym ]:
TETRAETHYLENE GLYCOL DI-P-TOSYLATE
Tetraethylene Glycol Bis(p-toluenesulfonate)
Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate)
Bis[2-(2-tosyloxyethoxy)ethyl] Ether
MFCD00075239

Biological Activity

[Description]:

PROTAC Linker 16 is a polyethylene glycol (PEG)-based PROTAC linker. PROTAC Linker 16 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.242 g/mL at 25ºC(lit.)

[ Boiling Point ]:
635ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₀O₉S₂

[ Molecular Weight ]:
502.59800

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
502.13300

[ PSA ]:
131.19000

[ LogP ]:
4.62560

[ Index of Refraction ]:
n20/D 1.53(lit.)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2909309090

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Bis(isoquinoline N-oxide) pincers as a new type of metal cation dual channel fluorosensor.

Org. Lett. 4(5) , 855-8, (2002)

[structure: see text] A new type of donor-spacer-acceptor podand system has been synthesized and proved as an efficient dual channel fluorosensor for Li+, Mg2+, and Ca2+. The known ability for the N-o...