(24S)-24,25-Dihydroxyvitamin D3

Names

[ CAS No. ]:
55700-58-8

[ Name ]:
(24S)-24,25-Dihydroxyvitamin D3

[Synonym ]:
GINSENOSIDE A1
pseudo-ginsenoside-Fll
(3b,6a,12b,24R)-20,24-Epoxy-3,12,25
(24S)-24,25-dihydroxyvitamin D3
24(S),25-dihydroxycholecalciferol
Pseuginsenoside F11
PSEUDOGINSENOSIDE
Pseudoginsenoside FII
(24R)-Pseudoginsenoside F11
24(S)-pseudo-ginsenoside-F11
pseudo-ginsenoside F11
Pseuginsensoside F11

Biological Activity

[Description]:

(24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. IC50 value:Target: Vitamin D3 analog1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24S,25-Dihydroxyvitamin D3 should not be confused with 24R,25-Dihydroxyvitamin D3.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR
Research Areas >> Others

[References]

[1]. Yamada S, Ino E, Takayama H et al. Differences in the side-chain metabolism of vitamin D3 between chickens and rats. Proc Natl Acad Sci U S A. 1985 Nov;82(22):7485-9.

[2]. Kobayashi N, Higashi T, Saito K et al. Specificity of polyclonal antibodies raised against a novel 24,25-dihydroxyvitamin D3-bovine serum albumin conjugant linked through the C-11alpha or C-3 position. J Steroid Biochem Mol Biol. 1997 May;62(1):79-87.

[3]. Larsson D, Nemere I, Sundell K. Putative basal lateral membrane receptors for 24,25-dihydroxyvitamin D(3) in carp and Atlantic cod enterocytes: characterization of binding and effects on intracellular calcium regulation. J Cell Biochem. 2001 Aug 1-9;83(2):171-86.

[4]. Nemere I, Yazzie-Atkinson D, Johns DO, Larsson D. Biochemical characterization and purification of a binding protein for 24,25-dihydroxyvitamin D3 from chick intestine. J Endocrinol. 2002 Jan;172(1):211-9.


[Related Small Molecules]

Calcipotriene | Maxacalcitol | Paricalcitol | Vitamin D3 | 25-Hydroxycalciferol | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | Secalciferol | Seocalcitol | 25,26-Dihydroxyvitamin D3 | Calcitetrol | Eldecalcitol | Ergocalciferol | Vitamin D4 | 24, 25-Dihydroxy VD2 | Calcipotriol Impurity C

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
571.1ºC at 760mmHg

[ Molecular Formula ]:
C27H44O3

[ Molecular Weight ]:
416.63600

[ Flash Point ]:
241.5ºC

[ Exact Mass ]:
416.32900

[ PSA ]:
60.69000

[ LogP ]:
5.70470

[ Index of Refraction ]:
1.547

MSDS

Click to get detail MSDS

Related Compounds