Porphobilinogen

Names

[ CAS No. ]:
487-90-1

[ Name ]:
Porphobilinogen

[Synonym ]:
EINECS 207-666-3
5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid
Porphobilinogen
MFCD00005224

Biological Activity

[Description]:

Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

Porphobilinogen can act as a phototoxin, a neurotoxin, and a metabotoxin. A phototoxin leads to cell damage upon exposure to light. A neurotoxin causes damage to nerve cells and nerve tissues. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels[1].

[References]

[1]. Winkelman JW, et al. Neurotoxicity of tetraphenylporphinesulfonate TPPS4 and its relation to photodynamic therapy. Photochem Photobiol. 1987 Nov;46(5):801-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.421g/cm3

[ Boiling Point ]:
478.6ºC at 760 mmHg

[ Melting Point ]:
174-177ºC

[ Molecular Formula ]:
C₁₀H₁₄N₂O₄

[ Molecular Weight ]:
226.22900

[ Flash Point ]:
243.2ºC

[ Exact Mass ]:
226.09500

[ PSA ]:
116.41000

[ LogP ]:
0.81800

[ Vapour Pressure ]:
5.74E-10mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

FASEB J. 29 , 3889-98, (2015)

The ubiquitin system plays a critical role in muscle wasting. Previous work has focused on the roles of ubiquitination. However, a role for deubiquitination in this process has not been established. B...

Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria.

J. Mass Spectrom. 50 , 929-37, (2015)

We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spe...

Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas.

Cancer Med. 3(1) , 1-13, (2014)

The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma (...