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Fmoc-N-amido-PEG2-alcohol

Names

[ CAS No. ]:
299430-87-8

[ Name ]:
Fmoc-N-amido-PEG2-alcohol

[Synonym ]:
AmbotzFAL3010

Biological Activity

[Description]:

Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.221g/cm3

[ Boiling Point ]:
547.8ºC at 760 mmHg

[ Molecular Formula ]:
C19H21NO4

[ Molecular Weight ]:
327.37400

[ Flash Point ]:
285.1ºC

[ Exact Mass ]:
327.14700

[ PSA ]:
67.79000

[ LogP ]:
2.92490

[ Vapour Pressure ]:
7.81E-13mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds