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N-[(4-Hydroxyphenyl)acetyl]glutamic acid

Names

[ CAS No. ]:
28047-15-6

[ Name ]:
N-[(4-Hydroxyphenyl)acetyl]glutamic acid

[Synonym ]:
N(2)-phenylacetyl-L-glutamine
(2S)-5-amino-5-oxo-2-[(2-phenylacetyl)amino]pentanoic acid
N-[(4-Hydroxyphenyl)acetyl]glutamic acid
Glutamic acid, N-[2-(4-hydroxyphenyl)acetyl]-
Phenylacetyl L-Glutamine

Biological Activity

[Description]:

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

[Related Catalog]:

Research Areas >> Others
Natural Products >> Others

[Target]

Human Endogenous Metabolite


[In Vitro]

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation. It results from glutamine conjugation of phenylacetic acid, which is almost exclusively derived from the microbial conversion of phenylalanine[1].

[References]

[1]. Poesen R, et al. Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD. J Am Soc Nephrol. 2016 Nov;27(11):3479-3487.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
646.6±55.0 °C at 760 mmHg

[ Melting Point ]:
85-87?C

[ Molecular Formula ]:
C13H16N2O4

[ Molecular Weight ]:
281.261

[ Flash Point ]:
344.9±31.5 °C

[ Exact Mass ]:
281.089935

[ PSA ]:
109.49000

[ LogP ]:
-1.38

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
Store at 0-5°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA2276800
CHEMICAL NAME :
Glutamine, N(sup 2)-(phenylacetyl)-, L-
CAS REGISTRY NUMBER :
28047-15-6
BEILSTEIN REFERENCE NO. :
2593680
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H16-N2-O4
MOLECULAR WEIGHT :
264.31
WISWESSER LINE NOTATION :
ZV2YVQMV1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 13,316,1977

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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