Levobupivacaine hydrochloride

Names

[ Name ]:
Levobupivacaine hydrochloride

[Synonym ]:
levobupivacaine monohydrochloride
Levobupivacainehydrochloride
(S)-(-)-BUPIVACAINE HCL
Levobupivacaine Hydrochloride
L-BUPIVACAINE HYDROCHLORIDE
L-(-)-Bupivacaine
(S)-Bupivacaine hydrochloride
(RS)-bupivacaine hydrochloride
BUPIVACAINE HCL
Levobupivacaine HCl
bupivacaine.hydrochloride
MFCD01704265
(-)-Bupivacaine hydrochloride
Chirocaine
(2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1)
2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, (2S)-, hydrochloride (1:1)
1-butyl-piperidine-2-carboxylic acid-(2,6-dimethyl-anilide),hydrochloride
LEVAMISOLHCLSALT
(2S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride (1:1)
(S)-(-)-Bupivacaine hydrochloride
(S)-Bupivacaine
(-)-Bupicaine Hydrochloride
bupicainehydrochloride(-)
Levobupivacaine (hydrochloride)

Biological Activity

[Description]:

Levobupivacaine Hcl is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Others

[References]

[1]. Burlacu CL, et al. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag. 2008 Apr;4(2):381-92.

[2]. Gulec D, et al. Intrathecal bupivacaine or levobupivacaine: which should be used for elderly patients? J Int Med Res. 2014 Apr;42(2):376-85.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
423.4ºC at 760 mmHg

[ Melting Point ]:
254 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₈H₂₉ClN₂O

[ Molecular Weight ]:
324.889

[ Flash Point ]:
209.9ºC

[ Exact Mass ]:
324.196838

[ PSA ]:
23.55000

[ LogP ]:
4.74080

[ Vapour Pressure ]:
2.24E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK6120000

CHEMICAL NAME :: 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride, (-)-

CAS REGISTRY NUMBER :: 27262-48-2

LAST UPDATED :: 198209

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H28-N2-O.Cl-H

MOLECULAR WEIGHT :: 324.94

WISWESSER LINE NOTATION :: T6NTJ A4 BVMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 207 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 200,359,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
T+: Very toxic;Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S36/37/39-S45-S36/37-S53

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TK6125000

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

Related Compounds

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