Boc-NH-PEG1-OH

Names

[ Name ]:
Boc-NH-PEG1-OH

[Synonym ]:
tert-Butyl (2-hydroxyethyl)carbamate
(2-hydroxyethyl)carbamic acid t-butyl ester
Boc-NH-(CH2)2-1-naphthylamide
boc-ethanolamine
Boc-2-aminoethanol
2-Boc-ethanolamine
2-(tert-Butoxycarbonyl)ethanolamine
2-(tert-ButoxycarbonylaMino)-1-ethanol
(2-hydroxy-ethyl)-carbamic acid tert-butyl ester
Carbamic acid, N-(2-hydroxyethyl)-, 1,1-dimethylethyl ester
MFCD00056657
N-(t-butoxycarbonyl)-2-hydroxy-ethylamine
N-(tert-Butoxycarbonyl)ethanolamine
2-(Boc-amino)-1-ethanol
N-(2-Hydroxyethyl)carbamic Acid tert-Butyl Ester
boc-aminoethanol
Boc-Gly-ol
Boc-glycinol
2-Methyl-2-propanyl (2-hydroxyethyl)carbamate
N-Boc-ethanolamine
tert-Butyl N-(2-Hydroxyethyl)carbamate
2-(tert-butoxycarbonylamino)ethanol
tert-butyl N-(2-hydroxyethyl)-carbamate

Biological Activity

[Description]:

Boc-NH-PEG1-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
267.2±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₅NO₃

[ Molecular Weight ]:
161.199

[ Flash Point ]:
115.4±22.6 °C

[ Exact Mass ]:
161.105194

[ PSA ]:
58.56000

[ LogP ]:
0.49

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.450

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R37/38;R41

[ Safety Phrases ]:
S26-S39-S45-S36/37/39

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ Hazard Class ]:
6.1

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis , 133, (1993)

Synth. Commun. 21 , 359, (1991)