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Boc-NH-PEG5-CH2CH2COOH

Names

[ CAS No. ]:
1347750-78-0

[ Name ]:
Boc-NH-PEG5-CH2CH2COOH

[Synonym ]:
2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid
3,8,11,14,17,20-Hexaoxa-5-azatricosan-23-oic acid, 2,2-dimethyl-4-oxo-
Boc-N-amido-PEG5-acid
BOC-PEG5-CH2CH2COOH
t-Boc-N-amido-PEG5-acid

Biological Activity

[Description]:

Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2017117474A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
536.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H35NO9

[ Molecular Weight ]:
409.472

[ Flash Point ]:
278.5±30.1 °C

[ Exact Mass ]:
409.231171

[ LogP ]:
-0.50

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.467

Related Compounds