Antiproliferative agent-6

Names

[ CAS No. ]:
2389016-82-2

[ Name ]:
Antiproliferative agent-6

Biological Activity

[Description]:

Antiproliferative against-6 (compound 8a) is a potent antitumor agent. Antiproliferative against-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

GI50: 0.5 μM (HCT116), 2 μM (MCF-7), 0.7 μM (H460), 3.5 μM (HaCaT)[1]


[References]

[1]. Meščić Macan A, et al. Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives. Eur J Med Chem. 2020;185:111845.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14ClFN6

[ Molecular Weight ]:
404.83

Related Compounds