Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-

Names

[ Name ]:
Phenol, 2-[6-fluoro-3-[[(4-methoxyphenyl)methyl]amino]imidazo[1,2-a]pyridin-2-yl]-

Biological Activity

[Description]:

Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vitro]

Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM)[1]. Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage[1].

[References]

[1]. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈FN₃O₂

[ Molecular Weight ]:
363.38