Antiproliferative agent-20

Names

[ CAS No. ]:
1344715-94-1

[ Name ]:
Antiproliferative agent-20

Biological Activity

[Description]:

Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Antiproliferative agent-20 (compound 5) (3.125 -50.0 μM; 24-96 h) 以剂量依赖的方式抑制 Bel-7402 细胞的增殖[1]。

[In Vivo]

Antiproliferative agent-20 (10-40 μg/egg) 抑制鸡尿囊绒毛膜 (CAM) 的血管生成[1]。 Antiproliferative agent-20 (3.2 g/kg; p.o.) 在两周内未显示小鼠死亡或毒性迹象[1]。 Antiproliferative agent-20 (24 h)在 37℃ 人工胃液和人工肠液中不发生水解[1]。

[References]

[1]. WANG PL, et, al. Synthesis and Antitumor Evaluation of One Novel Tetramethylpyrazine-Rhein Derivative. Asian Journal of Chemistry (2013), 25(9), 4885-4888.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H18N2O6

[ Molecular Weight ]:
418.40

Related Compounds