2,5,8,11,14,17-Hexaoxanonadecan-19-ol

Names

[ Name ]:
2,5,8,11,14,17-Hexaoxanonadecan-19-ol

[Synonym ]:
2,5,8,11,14,17-Hexaoxanonadecan-19-ol
hexa-PEG monomethyl ether
methoxy polyethyleneglycol tosylate
methoxyhexaethylene glycol
EINECS 245-775-8
2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
3,6,9,12,15,18-Hexaoxanonadecan-1-ol
Hexaethylene glycol monomethyl ether

Biological Activity

[Description]:

Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
375.6±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₈O₇

[ Molecular Weight ]:
296.357

[ Flash Point ]:
180.9±26.5 °C

[ Exact Mass ]:
296.183502

[ PSA ]:
75.61000

[ LogP ]:
-2.59

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.446

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%