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Z-FA-FMK

Names

[ CAS No. ]:
197855-65-5

[ Name ]:
Z-FA-FMK

[Synonym ]:
z-fa-fmk
UNII:34O3P3306Z
Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)phenylalaninamide
Carbamic acid, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
Carbamic acid, N-[2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
Nα-[(Benzyloxy)carbonyl]-N-(4-fluoro-3-oxo-2-butanyl)-L-phenylalaninamide

Biological Activity

[Description]:

Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) is a broad-spectrum halomethyl ketone inhibitor sgainst Coronavirus (SARS-CoV) main protease 3CL with a Ki of 25.7 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

Ki: 25.7 μM (SARS Protease 3CLpro)[1]


[References]

[1]. Usman Bacha, et al. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chem Biol Drug Des. 2008 Jul;72(1):34-49.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
630.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H23FN2O4

[ Molecular Weight ]:
386.417

[ Flash Point ]:
335.1±31.5 °C

[ Exact Mass ]:
386.164185

[ PSA ]:
84.50000

[ LogP ]:
3.67

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.549

[ Storage condition ]:
-15°C

Related Compounds