Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK

Names

[ CAS No. ]:
1381885-28-4

[ Name ]:
Z-VRPR-FMK(Z-Val-Arg-Pro-DL-Arg-FMK

[Synonym ]:
L-Phenylalanine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-
S-[2,3-Bis(palmitoyloxy)propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine

Biological Activity

[Description]:

Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> NF-κB >> MALT1

[In Vitro]

Z-VRPR-FMK(50 μM, 24 h)可以有效降低 HBL-1 细胞核 c-REL 水平，抑制了 NF-κB 的信号传导[2]。 Z-VRPR-FMK(50 μM, 48 h)对 ABC-DLBCL 细胞系 HBL-1, TMD8, OCI-Ly3 和 OCI-Ly10 具有一定的抑制增殖作用[2]。

[References]

[1]. Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955.   

[2]. Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22(6):812-24.   

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1659.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C84H140N14O18S

[ Molecular Weight ]:
1666.158

[ Flash Point ]:
957.6±34.3 °C

[ Exact Mass ]:
1665.019043

[ LogP ]:
15.83

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.553

Related Compounds