Z-FA-FMK

Names

[ CAS No. ]:
105637-38-5

[ Name ]:
Z-FA-FMK

Biological Activity

[Description]:

(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17(9):1567. Published 2016 Sep 16.  

[2]. Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7(24):36447-36460.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H23FN2O4

[ Molecular Weight ]:
386.41700

[ Exact Mass ]:
386.16400

[ PSA ]:
84.50000

[ LogP ]:
3.34920

Related Compounds