Alvimopan
Names
[ CAS No. ]:
170098-38-1
[ Name ]:
Alvimopan
[Synonym ]:
Alvimopan dihydrate
Alvimopan
N-{(2S)-2-Benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]propanoyl}glycine dihydrate
Glycine, N-[(2S)-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]-1-oxo-2-(phenylmethyl)propyl]-, hydrate (1:2)
Alvimopan (USAN)
Adl 8-2698
Alvimopan anhydrous
UNII-677C126AET
Alvimopan hydrate
Entereg
Alvimopan (dihydrate)
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.166g/cm3
[ Boiling Point ]:
684.1ºC at 760mmHg
[ Melting Point ]:
210-213ºC
[ Molecular Formula ]:
C25H36N2O6
[ Molecular Weight ]:
460.563
[ Flash Point ]:
367.5ºC
[ Exact Mass ]:
460.257324
[ PSA ]:
108.33000
[ LogP ]:
3.25160
[ Vapour Pressure ]:
1.18E-19mmHg at 25°C
[ Index of Refraction ]:
1.572
[ Storage condition ]:
-20℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MC0595275
- CHEMICAL NAME :
- Glycine, N-(2-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl )methyl)-1-oxo-3-phen ylpropyl)-,dihydrate, (3R-(1(S*),3-alpha,4-alpha))-
- CAS REGISTRY NUMBER :
- 170098-38-1
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C25-H32-N2-O4.2H2-O
- MOLECULAR WEIGHT :
- 460.63
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 19,1078,1994