MNK-IN-54

MNK-IN-54 is a potent, orally bioavailable dual MNK1/2 and BCR-ABL1 inhibitor with IC50 of 20/10/200/10 nM for Abl T315I/ wt Abl/MNK1/MNK2, respectively; also inhibits RET, FLT3, VEGFR2 with IC50 <20 nM; shows GI50 of 51 nM in the growth of K562 cells overexpressing eIF4E; exhibits antitumor activity in a mouse xenograft model and also reduces the level of phosphorylated eukaryotic translation initiation factor 4E in the tumor tissues.

References 1. Cherian J, et al. J Med Chem. 2016 Apr 14;59(7):3063-78. View Related Products by Target MNK