TRAP-14 trifluoroacetate salt

Names

[ Name ]:
TRAP-14 trifluoroacetate salt

[Synonym ]:
MFCD00133815
Thrombin Receptor Activator
Ser-phe-leu-leu-arg-asn-pro-asn-asp-lys-tyr-glu-pro-phe
TRAP
Thrombin Receptor Agonist Peptide
Thrombin Receptor Activator Peptide
Thrombin receptor agonist peptide-14
TRAP-14

Biological Activity

[Description]:

SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

Research Areas >> Cardiovascular Disease

[In Vitro]

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].

[References]

[1]. Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9.

[2]. Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10.

[3]. Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₁H₁₁₈N₂₀O₂₃

[ Molecular Weight ]:
1739.92000

[ Exact Mass ]:
1738.87000

[ PSA ]:
713.20000

[ LogP ]:
2.88170

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T

[ Risk Phrases ]:
61

[ Safety Phrases ]:
53-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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