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137339-65-2

137339-65-2 structure
137339-65-2 structure
  • Name: TRAP-14 trifluoroacetate salt
  • Chemical Name: sfllrnpndkyepf
  • CAS Number: 137339-65-2
  • Molecular Formula: C81H118N20O23
  • Molecular Weight: 1739.92000
  • Catalog: Biochemical Peptide
  • Create Date: 2018-03-24 08:00:00
  • Modify Date: 2025-08-22 16:49:00
  • SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.
Name sfllrnpndkyepf
Synonyms MFCD00133815
Thrombin Receptor Activator
Ser-phe-leu-leu-arg-asn-pro-asn-asp-lys-tyr-glu-pro-phe
TRAP
Thrombin Receptor Agonist Peptide
Thrombin Receptor Activator Peptide
Thrombin receptor agonist peptide-14
TRAP-14
Description SFLLRNPNDKYEPF is a synthetic thrombin receptor agonist peptide.
Related Catalog
In Vitro Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF. This peptide (TRP-14) may signal a variety of thrombin's responses[1]. SFLLRNPNDKYEPF, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. SFLLRNPNDKYEPF, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. SFLLRNPNDKYEPF is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion[2]. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin[3].
References

[1]. Sugama Y, et al. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism. Circ Res. 1992 Oct;71(4):1015-9.

[2]. Sabo T, et al. Structure-activity studies of the thrombin receptor activating peptide. Biochem Biophys Res Commun. 1992 Oct 30;188(2):604-10.

[3]. Maruyama Y, et al. Thrombin receptor agonist peptide decreases thrombomodulin activity in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1262-9.
Molecular Formula C81H118N20O23
Molecular Weight 1739.92000
Exact Mass 1738.87000
PSA 713.20000
LogP 2.88170
Storage condition −20°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T
Risk Phrases 61
Safety Phrases 53-45
RIDADR NONH for all modes of transport
WGK Germany 3
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title: CAS No. 137339-65-2 | Chemsrc address: https://www.chemsrc.com/en/baike/671820.html

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