Hydroxy-PEG2-(CH2)2-Boc

Names

[ Name ]:
Hydroxy-PEG2-(CH2)2-Boc

[Synonym ]:
9-hydroxy-4,7-dioxanonanoic acid tert-butyl ester
Propanoic acid,3-[2-(2-hydroxyethoxy)ethoxy]-,1,1-dimethylethyl ester
tert-butyl 3-[di(ethylene glycol)]propanoate
tert-butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate
Hydroxy-PEG2-t-butyl ester

Biological Activity

[Description]:

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂O₅

[ Molecular Weight ]:
234.28900

[ Exact Mass ]:
234.14700

[ PSA ]:
64.99000

[ LogP ]:
0.74370

Hydroxy-PEG2-(CH2)2-Boc

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds