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Hydroxy-PEG4-(CH2)2-Boc

Names

[ CAS No. ]:
518044-32-1

[ Name ]:
Hydroxy-PEG4-(CH2)2-Boc

[Synonym ]:
tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate
tert-butyl 1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate
tert-butyl 15-hydroxy-4,7,10,13-tetraoxapentadecanoate
tert-butyl-15-hydroxy-4,7,10,13-tetraoxapentadecanoate
t-butyl 15-hydroxy-4,7,10,13-tetraoxapentadecanoate
15-Hydroxy-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester

Biological Activity

[Description]:

Hydroxy-PEG4-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 191).

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H30O7

[ Molecular Weight ]:
322.39500

[ Exact Mass ]:
322.19900

[ PSA ]:
83.45000

[ LogP ]:
0.77690

Related Compounds