Hydroxy-PEG1-(CH2)2-Boc

Names

[ CAS No. ]:
671802-00-9

[ Name ]:
Hydroxy-PEG1-(CH2)2-Boc

[Synonym ]:
MFCD22056310

Biological Activity

[Description]:

Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.031±0.06 g/cm3(Predicted)

[ Boiling Point ]:
274.0±15.0℃at 760 mmHg

[ Molecular Formula ]:
C₉H₁₈O₄

[ Molecular Weight ]:
190.23700

[ Exact Mass ]:
190.12100

[ PSA ]:
55.76000

[ LogP ]:
0.72710

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi