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(S)-(-)-5-Fluorowillardiine hydrochloride

Names

[ CAS No. ]:
1321546-70-6

[ Name ]:
(S)-(-)-5-Fluorowillardiine hydrochloride

[Synonym ]:
L-Alanine, 3-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-, hydrochloride (1:1)
3-(5-Fluoro-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-L-alanine hydrochloride (1:1)
(S)-(-)-5-Fluorowillardiine (hydrochloride)

Biological Activity

[Description]:

(S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease

[References]

[1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21.

[2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41.

[3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.


[Related Small Molecules]

(+)-MK 801 Maleate | CNQX | N-Methyl-D-aspartic acid | ifenprodil tartrate | D-AP5(mM/ml) | DNQX | Ro 25-6981 maleate | Flupirtine maleate | Mibampator | CX546 | Naspm | Talampanel | Centrophenoxine hydrochloride | 24-Hydroxycholesterol

Chemical & Physical Properties

[ Molecular Formula ]:
C7H9ClFN3O4

[ Molecular Weight ]:
253.615

[ Exact Mass ]:
253.026566

Related Compounds