Tyrphostin AG 30

Names

[ Name ]:
Tyrphostin AG 30

[Synonym ]:
3.4-Dioxy-benzylidencyanessigsaeure
2-cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid
(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid
AG 30
2-Propenoic acid,2-cyano-3-(3,4-dihydroxyphenyl)-,(E)
Tyrphostin AG 30
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
Tyrophostin AG 30
2-Cyan-3-(3,4-dihydroxy-phenyl)-acrylsaeure

Biological Activity

[Description]:

Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42.

[2]. Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93.

Chemical & Physical Properties

[ Density]:
1.559g/cm3

[ Boiling Point ]:
465.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₇NO₄

[ Molecular Weight ]:
205.16700

[ Flash Point ]:
235.4ºC

[ Exact Mass ]:
205.03800

[ PSA ]:
101.55000

[ LogP ]:
1.08938

[ Vapour Pressure ]:
1.8E-09mmHg at 25°C

[ Index of Refraction ]:
1.717

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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