Ruthenium red

Names

[ Name ]:
Ruthenium red

[Synonym ]:
MFCD00011479
Ruthenium red
Ammoniated ruthenium oxychloride

Biological Activity

[Description]:

Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[Target]

ICa[2]

[In Vitro]

Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2]. Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2]. Ruthenium red (10 μM) blocks the sarcoplasmic Ca release channels or the mitochondrial Ca uptake, and blocks 26.7 % of the sodium current, and slowed its inactivation time-course in guinea-pig isolated ventricular heart cells[2].

[References]

[1]. Lashanda N Waller, et al. Ruthenium red staining for ultrastructural visualization of a glycoprotein layer surrounding the spore of Bacillus anthracis and Bacillus subtilis. J Microbiol Methods. 2004 Jul;58(1):23-30.

[2]. Claire O Malécot, et al. Ruthenium red as an effective blocker of calcium and sodium currents in guinea-pig isolated ventricular heart cells. Br J Pharmacol. 1998 Jun; 124(3): 465–472.

Chemical & Physical Properties

[ Density]:
3.11

[ Melting Point ]:
>500ºC

[ Molecular Formula ]:
Cl₆H₄₂N₁₄O₂Ru₃

[ Molecular Weight ]:
786.354

[ Exact Mass ]:
785.887817

[ PSA ]:
63.82000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
28439000

Articles

Ultrastructural morphologic changes in mycobacterial biofilm in different extreme condition.

Ultrastruct. Pathol. 39(1) , 38-48, (2015)

The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic ac...

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

Carcinogenesis 35(12) , 2787-97, (2014)

Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid (CB), which interacts with specific targets involved in carcinogenesis. Specifically, CBG potently blocks transient receptor ...

The Grapevine VvPMEI1 Gene Encodes a Novel Functional Pectin Methylesterase Inhibitor Associated to Grape Berry Development.

PLoS ONE 10 , e0133810, (2015)

Pectin is secreted in a highly methylesterified form and partially de-methylesterified in the cell wall by pectin methylesterases (PMEs). PME activity is expressed during plant growth, development and...