(±)-Hexanoylcarnitine chloride

Names

[ Name ]:
(±)-Hexanoylcarnitine chloride

[Synonym ]:
Ruthenium Red
DL-Hexanoylcarnitine chloride
DL-Caproylcarnitine chloride

Biological Activity

[Description]:

(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Scarale MG, et al. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes. 2022 Jun 1;71(6):1363-1370.

[2]. Obayashi H, et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. J Toxicol Sci. 2017;42(4):385-396.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₆ClNO₄

[ Molecular Weight ]:
295.80

[ Exact Mass ]:
295.15500

[ PSA ]:
63.60000

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2923900090

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Production of acyl-carnitines from the metabolism of [U-14C]3-methyl-2-oxopentanoate by rat liver and skeletal muscle mitochondria.

Clin. Invest. Med. 18(2) , 144-51, (1995)

A sensitive method of continuous on-line radio-high performance liquid chromatography (HPLC) was used to detect the specific radio-labelled acyl-carnitine esters derived from the oxidation of [U-14C]3...

Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle.

Pediatr. Res. 52(1) , 64-70, (2002)

Defects of mitochondrial fatty acid beta-oxidation are an important group of inherited metabolic disorders in children. Despite improved screening opportunities, diagnosis of these disorders is not of...

Metabolomics identifies perturbations in human disorders of propionate metabolism.

Clin. Chem. 53(12) , 2169-76, (2007)

We applied untargeted mass spectrometry-based metabolomics to the diseases methylmalonic acidemia (MMA) and propionic acidemia (PA).We used a screening platform that used untargeted, mass-based metabo...