α-松油烯

α-松油烯用途

α-Terpinene (Terpilene) 是一种单萜,存在于多种食品和芳香植物(例如 Mentha piperita)的精油中。α-Terpinene 对 Trypanosoma evansi 有活性,并可用于锥虫病的研究。α-Terpinene 还具有抗氧化和抗真菌特性。

α-松油烯名称

[ CAS 号 ]:
99-86-5

[ 中文名 ]:
松油烯

[ 英文名 ]:
alpha-Terpinene

[中文别名 ]:

[英文别名 ]:

a-Terpinene
α-Terpinene
Terpilene
Terpinene
α -Terpinene
alpha-terpinene
p-Mentha-1,3-diene
1-methyl-4-isopropyl-1,3-cyclohexadiene
1-methyl-4-propan-2-yl-cyclohexa-1,3-diene
L6U CUTJ AY1&1 D1

α-松油烯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[ 靶点 ]

Trypanosoma evansi[1]

[参考文献]

[1]. Matheus D Baldissera, et al. In Vitro and in Vivo Action of terpinen-4-ol, γ-Terpinene, and α-Terpinene Against Trypanosoma Evansi. Exp Parasitol. 2016 Mar;162:43-8.

[2]. Patricia R Quiroga, et al. Contribution of Organic Acids to α-Terpinene Antioxidant Activity. Food Chem. 2019 Mar 30;277:267-272.

[3]. Johanna Rudbäck, et al. α-Terpinene, an Antioxidant in Tea Tree Oil, Autoxidizes Rapidly to Skin Allergens on Air Exposure. Chem Res Toxicol. 2012 Mar 19;25(3):713-21.

[4]. B Oliva, et al. Antimycotic Activity of Melaleuca Alternifolia Essential Oil and Its Major Components. Lett Appl Microbiol. 2003;37(2):185-7.

α-松油烯物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
174.1±0.0 °C at 760 mmHg

[ 熔点 ]:
-59.03°C (estimate)

[ 分子式 ]:
C₁₀H₁₆

[ 分子量 ]:
136.234

[ 闪点 ]:
46.1±0.0 °C

[ 精确质量 ]:
136.125198

[ LogP ]:
4.53

[ 外观性状 ]:
Liquid | Clear colorless to light yellow

[ 蒸汽压 ]:
1.6±0.1 mmHg at 25°C

[ 折射率 ]:
1.476

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
95% ethanol: soluble1ml/2ml, clear, colorless | Soluble in ether, alcohol, and ethanol (100 mg/ml). Insoluble in water.

α-松油烯MSDS

α-松油烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8060000

CHEMICAL NAME :: p-Mentha-1,3-diene

CAS REGISTRY NUMBER :: 99-86-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L6U CUTJ AY1&1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,873,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - behavioral

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,477,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,477,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5037 No. of Facilities: 1539 (estimated) No. of Industries: 29 No. of Occupations: 27 No. of Employees: 40804 (estimated) No. of Female Employees: 9980 (estimated)

α-松油烯安全信息

[ 符号 ]:

GHS02, GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226-H302-H315-H319-H335-H411-H413

[ 警示性声明 ]:
P210-P261-P273-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R10

[ 安全声明 (欧洲) ]:
26-36/37-61-62

[ 危险品运输编码 ]:
UN 2319 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
OS8060000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

[ 海关编码 ]:
3805909000

α-松油烯合成路线

α-松油烯上下游产品

α-松油烯上游产品

α-松油烯下游产品

α-松油烯制备

1. 烟草：FC，18。

2. 合成：柑橘类精油脱萜产物经进一步真空分馏而得；或用松节油中的蒎烯在酸催化下经异构体化反应制得。

α-松油烯海关

[ 海关编码 ]: 2902199090

[ 中文概述 ]:
2902199090 其他环烷烃、环烯烃及环萜烯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

α-松油烯文献

Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.

Molecules 17(9) , 10159-77, (2012)

Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. Historical and traditional uses are extensively docu...

Antimicrobial and antioxidant activities of essential oils of Satureja thymbra growing wild in Libya.

Molecules 17(5) , 4836-50, (2012)

The composition of essential oil isolated from Satureja thymbra, growing wild in Libya, was analyzed by GC and GC-MS. The essential oil was characterized by γ-terpinene (39.23%), thymol (25.16%), p-cy...

Variation of volatiles in Tunisian populations of Thymbra capitata (L.) Cav. (Lamiaceae).

Chem. Biodivers. 9(7) , 1272-85, (2012)

Volatiles from 14 wild Tunisian populations of Thymbra capitata (=Thymus capitatus Hoffmanns. et Link=Coridothymus capitatus Rchb.f.), sampled in five ecological areas (sub-humid, upper semi-arid, mea...

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