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卡律(布德)蝎毒素

卡律(布德)蝎毒素用途

Charybdotoxin 是一种含 37 个氨基酸的肽,可从蝎子 Leiurus quinquestriatus var. hebraeus 中分离得到的。Charybdotoxin 是一个 K+ 通道阻滞剂。

卡律(布德)蝎毒素名称

[ CAS 号 ]:
95751-30-7

[ 中文名 ]:
卡律(布德)蝎毒素

[ 英文名 ]:
Charybdotoxin

[英文别名 ]:

MFCD00146378

卡律(布德)蝎毒素生物活性

[ 描述 ]:

Charybdotoxin 是一种含 37 个氨基酸的肽,可从蝎子 Leiurus quinquestriatus var. hebraeus 中分离得到的。Charybdotoxin 是一个 K+ 通道阻滞剂。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> 钾通道

[体外研究]

Charybdotoxin是研究K+通道的一个重要工具[1]。

[参考文献]

[1]. M L Garcia , et al. Charybdotoxin and its effects on potassium channels. Am J Physiol. 1995 Jul;269(1 Pt 1):C1-10.

卡律(布德)蝎毒素物理化学性质

[ 分子式 ]:
C₁₇₆H₂₇₇N₅₇O₅₅S₇

[ 分子量 ]:
4295.89

卡律(布德)蝎毒素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

卡律(布德)蝎毒素文献

Triclosan, an environmental pollutant from health care products, evokes charybdotoxin-sensitive hyperpolarization in rat thymocytes.

Environ. Toxicol. Pharmacol. 32(3) , 417-22, (2011)

The effects of triclosan, an environmental pollutant from household items and health care products, on membrane potential and intracellular Ca(2+) concentrations of rat thymocytes were examined by a f...

Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.

Life Sci. 92(23) , 1131-7, (2013)

Rheumatoid arthritis (RA) is associated with high cardiovascular mortality. Impaired endothelial cell (EC) function and elevated angiotensin II levels may be central to the link between vascular dysfu...

The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.

Am. J. Physiol. Lung Cell. Mol. Physiol. 303(11) , L956-66, (2012)

Activation of taste receptors (TAS2Rs) by bitter taste agonists has been reported to cause bronchodilation. The aim of this study was to extend the information on the effects of bitter taste agonists ...

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