玛格斑蝎毒素

玛格斑蝎毒素用途

Margatoxin 是一种 α-KTx 蝎毒素,一种高亲和力的 Kv1.3 抑制剂,Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道,Kd 值分别为 6.4 pM,4.2 nM。Margatoxin 是一种 39 个氨基酸的肽,是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的,广泛用于离子通道研究。

玛格斑蝎毒素名称

[ CAS 号 ]:
145808-47-5

[ 中文名 ]:
玛格斑蝎毒素

[ 英文名 ]:
Margatoxin

玛格斑蝎毒素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1]

[体内研究]

Margatoxin(i.p.；1pmol/g)显著降低12周龄C57BL6/J小鼠腹腔内由硫草胺诱导的白细胞迁移[2]。

[参考文献]

[1]. Bartok A, et al. Margatoxin is a non-selective inhibitor of human Kv1.3 K⁺ channels. Toxicon. 2014 Sep;87:6-16.

[2]. Chen YC, et al. PreImplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids. Thromb Haemost. 2016 May 2;115(5):1010-24.

玛格斑蝎毒素物理化学性质

[ 分子式 ]:
C₁₇₈H₂₈₆N₅₂O₅₀S₇

玛格斑蝎毒素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

玛格斑蝎毒素文献

Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.

Toxicology 289(1) , 11-8, (2011)

Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects ...

Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

J. Phys. Chem. B 116(17) , 5132-40, (2012)

The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was...

Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.

Am. J. Physiol. Cell Physiol. 301(5) , C1186-200, (2011)

We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2...

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