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酞磺胺噻唑

酞磺胺噻唑用途

Phthalylsulfathiazole是一种磺胺类抗菌药。

酞磺胺噻唑名称

[ CAS 号 ]:
85-73-4

[ 中文名 ]:
酞磺胺噻唑

[ 英文名 ]:
Phthalylsulfathiazole

[中文别名 ]:

羧苯甲酰磺胺噻唑

[英文别名 ]:

Cremothalidine
Phthalylsulfathiazole
Taloudron
Ftalazol
N-(4-thiazol-2-ylsulfamoyl-phenyl)-phthalamic acid
Talidine
entexidin
Phtalazol
EINECS 201-627-4
Sulftalyl

酞磺胺噻唑生物活性

[ 描述 ]:

Phthalylsulfathiazole是一种磺胺类抗菌药。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 其他

[参考文献]

[1]. S. RAGHAV, et al. Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole. ACS Symposium Series, 1985: 447-460

[相关活性小分子]

酞磺胺噻唑物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
579ºC at 760 mmHg

[ 熔点 ]:
198-204°C

[ 分子式 ]:
C₁₇H₁₃N₃O₅S₂

[ 分子量 ]:
403.432

[ 闪点 ]:
304ºC

[ 精确质量 ]:
403.029663

[ PSA ]:
162.08000

[ LogP ]:
1.54

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 折射率 ]:
1.715

[ 储存条件 ]:
-20°C

酞磺胺噻唑MSDS

酞磺胺噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8575000

CHEMICAL NAME :: Phthalanilic acid, 4'-(2-thiazolylsulfamoyl)-

CAS REGISTRY NUMBER :: 85-73-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H13-N3-O5-S2

MOLECULAR WEIGHT :: 403.45

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DMVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,116,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12900 mg/kg/30D-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of esophagus

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84641 No. of Facilities: 193 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 9471 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84641 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

酞磺胺噻唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
3249

[ RTECS号 ]:
TH8575000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2935009090

酞磺胺噻唑合成路线

酞磺胺噻唑上下游产品

酞磺胺噻唑上游产品

酞磺胺噻唑下游产品

酞磺胺噻唑制备

磺胺噻唑（ST）与苯酐进行酰化反应即得粗PST，经精制得到成品。将ST及苯酐充分混匀，140℃反应1.5h。将所得粗品加入水中，用液碱调节pH至8，全溶后在40℃加活性炭脱色半小时，过滤，滤液用盐酸中和至pH=5-6，过滤，洗涤滤饼，干燥、粉碎得成品PST。

酞磺胺噻唑海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

酞磺胺噻唑文献

[Experimental basis for the tentative permissible levels of phthalazol, sulfadimethoxine and Bepask in bodies of water].

Gig. Sanit. (12) , 9-10, (1993)

Tentative permissible levels (TPL) of phthalazol, sulfadimethoxine, and Bepask in the water were substantiated on the basis of study of organoleptic properties, of influence on sanitary status of wate...

The effect of antibacterial agents on the intestinal flora of patients: the use of aureomycin, chloromycetin, dihydrostreptomycin, sulfasuxidine and sulfathalidine.

Gastroenterology 16(1) , 12-8, (1950)

The effects of phthalylsulphathiazole on the bacteria of the colonic mucosa and intestinal contents as revealed by the examination of surgical samples.

Scand. J. Gastroenterol. 14(7) , 891-6, (1979)

The isolation of a bacterial flora specifically associated with the colonic mucosa of patients undergoing large-bowel surgery is described. This flora differed from that of faeces in both the numbers ...

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