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灰叶草素, 羟基鱼藤素

灰叶草素, 羟基鱼藤素用途

Tephrosin 是一种天然类胡萝卜素,具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。

灰叶草素, 羟基鱼藤素名称

[ CAS 号 ]:
76-80-2

[ 中文名 ]:
灰叶草素, 羟基鱼藤素

[ 英文名 ]:
Tephrosin

[英文别名 ]:

Tephrosin
Toxicarol
Hydroxydeguelin

灰叶草素, 羟基鱼藤素生物活性

[ 描述 ]:

Tephrosin 是一种天然类胡萝卜素,具有较强的抗肿瘤活性。Tephrosin 通过诱导受体内化来诱导 EGFR 和 ErbB2 的降解。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

用tephrosin(0-10μM)处理HT-29细胞抑制EGFR,ErbB2和ErbB3的配体诱导和组成型磷酸化,并同时抑制下游信号分子如Akt和Erk1/2丝裂原活化蛋白激酶的活化。(MAPK)[1]。

[参考文献]

[1]. Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293(1):23-30.

灰叶草素, 羟基鱼藤素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
623.4±55.0 °C at 760 mmHg

[ 熔点 ]:
198° (218-220°)

[ 分子式 ]:
C₂₃H₂₂O₇

[ 分子量 ]:
410.417

[ 闪点 ]:
219.3±25.0 °C

[ 精确质量 ]:
410.136566

[ PSA ]:
83.45000

[ LogP ]:
4.48

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
?20°C

灰叶草素, 羟基鱼藤素MSDS

详细MSDS(安全技术说明书)

灰叶草素, 羟基鱼藤素安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 危险类别 ]:
9.0

灰叶草素, 羟基鱼藤素上下游产品

灰叶草素, 羟基鱼藤素上游产品

灰叶草素, 羟基鱼藤素下游产品

灰叶草素, 羟基鱼藤素文献

[Rotenoids from Derris trifoliata].

Zhong Yao Cai 30(6) , 660-2, (2007)

Five rotenoids named dehydrodeguelin, dehydrorotenone, 12a-hydroxy rotenone, tephrosin and 12alphabeta-hydroxyrot-2'-enonic acid were isolated from aerial parts of Derris trifoliata. All these compoun...

Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography.

J. Chromatogr. A. 1178(1-2) , 101-7, (2008)

Both analytical and preparative high-speed counter-current chromatography (HSCCC) were used to isolate and separate chemical bioactive constituents from the seeds of Millettia pachycarpa Benth, a famo...

Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.

Pest Manag. Sci. 59(10) , 1159-61, (2003)

A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera:...

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