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木犀草素; 3',4',5,7-四羟基黄酮

木犀草素; 3',4',5,7-四羟基黄酮用途

木樨草素 (Luteolin)是一种天然黄酮类化合物,在抗癌方面具有非常重要的潜能。

木犀草素; 3',4',5,7-四羟基黄酮名称

[ CAS 号 ]:
491-70-3

[ 中文名 ]:
木犀草素

[ 英文名 ]:
Luteolin

[中文别名 ]:

[英文别名 ]:

EINECS 207-741-0
Flavopurpol
5,7,3',4'-tetrahydroxyflavon
3' 4' 5 7-tetrahydroxyflavone
LUTEOLOL
3',4',5,7-tetrahydroxy-flavone
FLACITRAN
Cyanidenon 1470
Digitoflavone
5,7,3',4'-tetrahydroxyflavone

木犀草素; 3',4',5,7-四羟基黄酮生物活性

[ 描述 ]:

木樨草素 (Luteolin)是一种天然黄酮类化合物,在抗癌方面具有非常重要的潜能。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 黄酮类化合物

研究领域 >> 癌症

[参考文献]

[1]. Liping Ma, et al. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis. Molecular MedicineReports, 2015, 12 (3): 4196-4202

[2]. Su Bog Yee, et al. Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. International Journal of Oncology, 2015, 47 (2): 747-754

[3]. Pang Tao, et al. Effect of Luteolin on the Improvement of Cancerous Cachexia in Model Mice. China Pharmacy, 2015-07

[4]. Divyashree Ravishankar, et al. Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal ChemistryVolume 97, 5 June 2015, Pages 259–274

[相关活性小分子]

木犀草素; 3',4',5,7-四羟基黄酮物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
616.1±55.0 °C at 760 mmHg

[ 熔点 ]:
~330 °C(lit.)

[ 分子式 ]:
C₁₅H₁₀O₆

[ 分子量 ]:
286.236

[ 闪点 ]:
239.5±25.0 °C

[ 精确质量 ]:
286.047729

[ PSA ]:
111.13000

[ LogP ]:
2.40

[ 外观性状 ]:
黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.768

[ 储存条件 ]:
2-8°C

木犀草素; 3',4',5,7-四羟基黄酮MSDS

详细MSDS(安全技术说明书)

木犀草素; 3',4',5,7-四羟基黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK9275210

CHEMICAL NAME :: Flavone, 3',4',5,7-tetrahydroxy-

CAS REGISTRY NUMBER :: 491-70-3

BEILSTEIN REFERENCE NO. :: 0292084

LAST UPDATED :: 199806

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-O6

MOLECULAR WEIGHT :: 286.25

WISWESSER LINE NOTATION :: T66 BO EVT&J CR CQ DQ& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

木犀草素; 3',4',5,7-四羟基黄酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LK9275210

[ 海关编码 ]:
2932999099

木犀草素; 3',4',5,7-四羟基黄酮上下游产品

木犀草素; 3',4',5,7-四羟基黄酮上游产品

木犀草素; 3',4',5,7-四羟基黄酮下游产品

木犀草素; 3',4',5,7-四羟基黄酮制备

可用半合成或全合成方法而制得。

木犀草素; 3',4',5,7-四羟基黄酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

木犀草素; 3',4',5,7-四羟基黄酮文献

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.

PLoS ONE 10 , e0137106, (2015)

Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will ...

Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumarium.

Bioorg. Med. Chem. 23 , 4746-54, (2015)

The ability of TRAIL to selectively induce apoptosis in cancer cells while sparing normal cells makes it an attractive target for the development of new cancer therapy. In search of bioactive natural ...

Metabolite profiling of polyphenols in the Tunisian plant Tamarix aphylla (L.) Karst.

J. Pharm. Biomed. Anal. 99 , 97-105, (2014)

In this study, a detailed investigation on the composition of polyphenols of Tamarix aphylla (L.) Karst., consisting of phenolic acids and flavonoids, was carried out. In order to optimize the yield o...

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