N-甲酰脱乙酰秋水仙碱
N-甲酰脱乙酰秋水仙碱名称
[ CAS 号 ]:
7411-12-3
[ 中文名 ]:
N-甲酰脱乙酰秋水仙碱
[ 英文名 ]:
Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
[英文别名 ]:
- Formyldescaetylcolchicine,N
- N-deacetyl-N-formylcolchicine
- N-Formyldeacetylcolchicine
- N-Desacetyl-N-formyl-colchicin
- COLCHICINE,N-DEACETYL-N-FORMYL
- Gloriosine
- N-formyl-N-deacetylcolchicine
- N-Formyldesacetylcolchicine
N-甲酰脱乙酰秋水仙碱物理化学性质
[ 密度 ]:
1.27g/cm3
[ 沸点 ]:
715.8ºC at 760 mmHg
[ 熔点 ]:
264-267ºC
[ 分子式 ]:
C21H23NO6
[ 分子量 ]:
385.41000
[ 闪点 ]:
386.7ºC
[ 精确质量 ]:
385.15300
[ PSA ]:
83.09000
[ LogP ]:
3.50830
[ 折射率 ]:
1.591
N-甲酰脱乙酰秋水仙碱毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0794000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N-formyl-
- CAS REGISTRY NUMBER :
- 7411-12-3
- BEILSTEIN REFERENCE NO. :
- 2824080
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C21-H23-N-O6
- MOLECULAR WEIGHT :
- 385.45
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMVH NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4400 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2666 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9200 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
N-甲酰脱乙酰秋水仙碱安全信息
[ 海关编码 ]:
2924299090
N-甲酰脱乙酰秋水仙碱合成路线
N-甲酰脱乙酰秋水仙碱海关
[ 海关编码 ]: 2924299090
[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 包装
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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