7411-12-3

• 常用中文名：N-甲酰脱乙酰秋水仙碱
• 常用英文名：Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：7411-12-3
• 分子式：C₂₁H₂₃NO₆
• 分子量：385.41000
• 发布时间：2018-06-20 22:18:28
• 更新时间：2024-01-07 20:41:48

名称

• 中文名: N-甲酰脱乙酰秋水仙碱
• 英文名: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
• 英文别名: Formyldescaetylcolchicine,N; N-deacetyl-N-formylcolchicine; N-Formyldeacetylcolchicine; N-Desacetyl-N-formyl-colchicin; COLCHICINE,N-DEACETYL-N-FORMYL; N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid; Gloriosine; N-formyl-N-deacetylcolchicine; N-Formyldesacetylcolchicine; (S)-7-Formylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on; N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide

物化性质

• 密度: 1.27g/cm3
• 沸点: 715.8ºC at 760 mmHg
• 熔点: 264-267ºC
• 分子式: C₂₁H₂₃NO₆
• 分子量: 385.41000
• 闪点: 386.7ºC
• 精确质量: 385.15300
• PSA: 83.09000
• LogP: 3.50830
• 折射率: 1.591

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0794000 CHEMICAL NAME : Colchicine, N-deacetyl-N-formyl- CAS REGISTRY NUMBER : 7411-12-3 BEILSTEIN REFERENCE NO. : 2824080 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H23-N-O6 MOLECULAR WEIGHT : 385.45 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JMVH NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2666 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9200 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

安全

• 海关编码: 2924299090

合成路线

64-18-6 3476-50-4 ~% 7411-12-3

文献：Raffauf et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 3854

186581-53-3 ~% 7411-12-3

文献：Santavy; Reichstein Helvetica Chimica Acta, 1950 , vol. 33, p. 1606,1625

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%