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磺胺二甲唑

磺胺二甲唑用途

Sulfamoxole 是一种广谱化疗抗菌(antimicrobial agent) 试剂。Sulfamoxole 可用于小儿感染的相关研究。

磺胺二甲唑名称

[ CAS 号 ]:
729-99-7

[ 中文名 ]:
磺胺二甲唑

[ 英文名 ]:
sulfamoxol

[中文别名 ]:

[英文别名 ]:

SULFAMOXOLE
Sulfamoxol
Sulphamoxole
Sulfavigor
sulphamoxazole
Oxasulfa
Sulfmidil
Sulfadimethyloxazole
Sulfamoxolum
Justamil

磺胺二甲唑生物活性

[ 描述 ]:

Sulfamoxole 是一种广谱化疗抗菌(antimicrobial agent) 试剂。Sulfamoxole 可用于小儿感染的相关研究。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. F Lagler, R Kretzschmar, et al. Toxicological Investigations of the Combination Sulfamoxole/Trimethoprim, a New Broad-Spectrum Chemotherapeutic. Arzneimittelforschung. 1976;26(42):634-43.

[2]. J A DUGGER, et al. Sulfamoxole (Nuprin), a New Sulfonamide, in Pediatric Practice. J New Drugs. Sep-Oct 1961;1:223-9.

磺胺二甲唑物理化学性质

[ 密度 ]:
1.411g/cm3

[ 沸点 ]:
481ºC at 760 mmHg

[ 熔点 ]:
197-199℃

[ 分子式 ]:
C₁₁H₁₃N₃O₃S

[ 分子量 ]:
267.30400

[ 闪点 ]:
244.7ºC

[ 精确质量 ]:
267.06800

[ PSA ]:
106.60000

[ LogP ]:
3.40940

[ 折射率 ]:
1.626

[ 储存条件 ]:
库房通风低温干燥

磺胺二甲唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9150000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4,5-dimethyl-2-oxazolyl)-

CAS REGISTRY NUMBER :: 729-99-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H13-N3-O3-S

MOLECULAR WEIGHT :: 267.33

WISWESSER LINE NOTATION :: T5N COJ BMSWR DZ& D1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1525 mg/kg/9W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Endocrine - changes in pituitary weight Endocrine - changes in thyroid weight

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,617,1960

磺胺二甲唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
43

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
WO9150000

磺胺二甲唑合成路线

详细合成路线

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磺胺二甲唑文献

Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis.

Adverse Drug React. Toxicol. Rev. 15(1) , 9-50, (1996)

Combination of trimethoprim with sulfonamides other than sulfamethoxazole.

Rev. Infect. Dis. 4(2) , 411-8, (1982)

Early in the development of trimethoprim (TMP), the response to the drug was less than enthusiastic. Preliminary clinical trials were performed with sulfonamides that were unsuitable partners. On the ...

Use of p-benzoquinone for the spectrophotometric determination of certain sulphonamides.

J. Pharm. Biomed. Anal. 9(7) , 531-8, (1991)

A simple spectrophotometric method for the determination of 15 sulphonamides in bulk and in dosage forms is described. The method is based on the interaction of p-benzoquinone with sulphonamides in 0....

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