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鸭嘴花碱盐酸盐

鸭嘴花碱盐酸盐用途

Vasicine hydrochloride (peganine hydrochloride) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。

鸭嘴花碱盐酸盐名称

[ CAS 号 ]:
7174-27-8

[ 中文名 ]:
鸭嘴花碱盐酸盐

[ 英文名 ]:
Vasicine hydrochloride

[英文别名 ]:

Peganine monohydrochloride
linarinehydrochloride
Vasicine Hcl

鸭嘴花碱盐酸盐生物活性

[ 描述 ]:

Vasicine hydrochloride (peganine hydrochloride) 是一种喹唑啉类生物碱,可从Justicia adhatoda 中分离得到。Vasicine (peganine) 具有抗结核活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50(1):49-53.

鸭嘴花碱盐酸盐物理化学性质

[ 沸点 ]:
373.8ºC at 760 mmHg

[ 熔点 ]:
206-208ºC

[ 分子式 ]:
C₁₁H₁₃ClN₂O

[ 分子量 ]:
224.68700

[ 闪点 ]:
179.9ºC

[ 精确质量 ]:
224.07200

[ PSA ]:
35.83000

[ LogP ]:
1.47230

[ 储存条件 ]:
室温

鸭嘴花碱盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY9454100

CHEMICAL NAME :: Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-, monohydrochloride, (R)-

CAS REGISTRY NUMBER :: 7174-27-8

LAST UPDATED :: 199510

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H12-N2-O.Cl-H

MOLECULAR WEIGHT :: 224.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,474,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 49(3),37,1986

鸭嘴花碱盐酸盐

鸭嘴花碱盐酸盐用途

鸭嘴花碱盐酸盐名称

鸭嘴花碱盐酸盐生物活性

鸭嘴花碱盐酸盐物理化学性质

鸭嘴花碱盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

鸭嘴花碱盐酸盐合成路线

详细合成路线

鸭嘴花碱盐酸盐上下游产品

鸭嘴花碱盐酸盐上游产品

鸭嘴花碱盐酸盐下游产品

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