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异山梨醇

异山梨醇用途

Isosorbide用作利尿剂,用于治疗脑积水,也用于治疗青光眼

异山梨醇名称

[ CAS 号 ]:
652-67-5

[ 中文名 ]:
异山梨醇

[ 英文名 ]:
Isosorbide

[中文别名 ]:

[英文别名 ]:

Isosorbid
EINECS 211-492-3
D-Glucitol, 1,4:3,6-dianhydro-
D-Isosorbide
dianhydro-D-sorbitol
Isosorbide
dianhydro-D-glucitol
L-Glucitol, 1,4:3,6-dianhydro-
hydronol
1,4:3,6-Dianhydro-D-glucitol

异山梨醇生物活性

[ 描述 ]:

Isosorbide用作利尿剂,用于治疗脑积水,也用于治疗青光眼

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 心血管疾病

[相关活性小分子]

异山梨醇物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
372.1±42.0 °C at 760 mmHg

[ 熔点 ]:
60-63 °C(lit.)

[ 分子式 ]:
C₆H₁₀O₄

[ 分子量 ]:
146.141

[ 闪点 ]:
178.8±27.9 °C

[ 精确质量 ]:
146.057907

[ PSA ]:
58.92000

[ LogP ]:
-1.75

[ 外观性状 ]:
灰白色至淡黄色或米色晶体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

异山梨醇MSDS

详细MSDS(安全技术说明书)

异山梨醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4380000

CAS REGISTRY NUMBER :: 652-67-5

BEILSTEIN REFERENCE NO. :: 0080510

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H10-O4

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: L44TJ BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6870 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in cerebral spinal fluid

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

异山梨醇安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
2

[ RTECS号 ]:
LZ4380000

[ 海关编码 ]:
2932999099

异山梨醇合成路线

详细合成路线

异山梨醇上下游产品

异山梨醇上游产品

异山梨醇下游产品

异山梨醇海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%