N-甲基多巴胺

N-甲基多巴胺用途

N-甲基多巴胺盐酸盐是肾上腺髓质中肾上腺素的前体。N-甲基多巴胺盐酸盐是多巴胺(DA)的修饰,并保留DA1受体的激动剂活性。N-甲基多巴胺盐酸盐仍然能够使用表面邻苯二酚进行通用表面涂覆和二次反应。N-甲基多巴胺盐酸盐可用于心力衰竭研究[1][2][3]。

N-甲基多巴胺名称

[ CAS 号 ]:
62-32-8

[ 中文名 ]:
盐酸N-甲基多巴胺

[ 英文名 ]:
n-methyldopamine hydrochloride

[中文别名 ]:

[英文别名 ]:

Ephinine hydrochloride
MFCD00035074
N-Methyldopamine hydrochloride
3,4-Dihydroxyphenylethylmethylamine hydrochloride
EPININE HCl
3,4-dihydroxyphenethylmethylammonium chloride
Methyldopamine hydrochloride
EINECS 200-528-3
Deoxyepinephrine hydrochloride
Epinine hydrochloride

N-甲基多巴胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

D1 Receptor

[体外研究]

N-甲基多巴胺盐酸盐显示出高度改善的表面涂覆性能,并显示出加速的涂覆速率。N-甲基多巴胺盐酸盐涂层使固体表面细胞粘附成为可能,涂层的后功能化也是可能的[1]。

[参考文献]

[1]. Kim Y, et al. Effect of N-Methylation on Dopamine Surface Chemistry. Langmuir. 2022 May 24;38(20):6404-6410.

[2]. Laduron P. N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:304-.

[3]. Rajfer SI, et al. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Circulation. 1986 Apr;73(4):740-8.

N-甲基多巴胺物理化学性质

[ 沸点 ]:
328.6ºC at 760 mmHg

[ 熔点 ]:
174-176ºC

[ 分子式 ]:
C₉H₁₄ClNO₂

[ 分子量 ]:
203.666

[ 闪点 ]:
154.3ºC

[ 精确质量 ]:
203.071304

[ PSA ]:
52.49000

[ LogP ]:
2.05260

[ 外观性状 ]:
solid | white

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble

N-甲基多巴胺MSDS

N-甲基多巴胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1925000

CHEMICAL NAME :: Pyrocatechol, 4-(2-(methylamino)ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 62-32-8

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H13-N-O2.Cl-H

MOLECULAR WEIGHT :: 203.69

WISWESSER LINE NOTATION :: QR BQ D2M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1194,1975 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

N-甲基多巴胺安全信息

[ 危害码 (欧洲) ]:
Xi

[ WGK德国 ]:
3

[ RTECS号 ]:
UX1925000

[ 海关编码 ]:
2922299090

N-甲基多巴胺合成路线

N-甲基多巴胺上下游产品

N-甲基多巴胺上游产品

N-甲基多巴胺下游产品

N-甲基多巴胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%