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S-亚硝基谷胱甘肽

S-亚硝基谷胱甘肽用途

亚硝基谷胱甘肽(GSNO),一种外源性NO供体和大鼠酒精脱氢酶III类同工酶的底物,抑制脑血管紧张素II依赖性和非依赖性AT1受体反应[1][2][3][4]。

S-亚硝基谷胱甘肽名称

[ CAS 号 ]:
57564-91-7

[ 中文名 ]:
N-(N-L-γ-谷氨酰基-S-亚硝基-L-半胱氨酰----甘氨酸

[ 英文名 ]:
L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

[中文别名 ]:

[英文别名 ]:

L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
glycine, N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-
Glycine, L-γ-glutamyl-S-nitroso-L-cysteinyl-
S-Nitroso-L-glutathione
S-NITROSOGLUTATHIONE
MFCD00214341
EINECS 248-170-7

S-亚硝基谷胱甘肽生物活性

[ 描述 ]:

亚硝基谷胱甘肽(GSNO),一种外源性NO供体和大鼠酒精脱氢酶III类同工酶的底物,抑制脑血管紧张素II依赖性和非依赖性AT1受体反应[1][2][3][4]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

[体外研究]

亚硝基谷胱甘肽(GSNO,250μM)在经LY-83583处理的环中阻止90%对0.1μM 5-HT的反应和40%对1.0μM 5-HT的反应,表明GSNO的作用独立于鸟苷酸环化酶活性[5]。

[体内研究]

亚硝基谷胱甘肽(GSNO,8 mg/kg)显著降低PE诱导大鼠从第14天到第20天的收缩压、舒张压和平均动脉压[3]。亚硝基谷胱甘肽(GSNO,0.2和0.6 mg/kg)显著抑制超氧化物的产生,抑制NF-κB活化、iNOS诱导和3-硝基酪氨酸表达,但上调皮瓣血管内皮NOS的表达[4]。动物模型：雄性Lewis大鼠[4]。剂量：0.2和0.6 mg/kg。给药：通过对侧股静脉向每只大鼠缓慢静脉注射。结果：再灌注前每千克0.2mg GSNO治疗的动物有中等存活率(40.2±4.9%)。尽管0.6 mg/kg的GSNO比150 mg/kg的NAC显示出更好的抢救效果,但两组之间没有显著差异。

[参考文献]

[1]. Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062.

[2]. D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):659-68.

[3]. Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4(2):330-5.

[4]. Yur-Ren Kuo, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57(5):1025-31.

[5]. Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1057-65.

S-亚硝基谷胱甘肽物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 熔点 ]:
>170ºC (dec.)

[ 分子式 ]:
C₁₀H₁₆N₄O₇S

[ 分子量 ]:
336.322

[ 精确质量 ]:
336.073975

[ PSA ]:
213.55000

[ LogP ]:
-0.26

[ 外观性状 ]:
粉红色粉末

[ 折射率 ]:
1.656

[ 储存条件 ]:
−20°C

S-亚硝基谷胱甘肽MSDS

详细MSDS(安全技术说明书)

S-亚硝基谷胱甘肽毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0558000

CHEMICAL NAME :: Glycine, N-(N-L-gamma-glutamyl-2-nitroso-L-cysteinyl)-

CAS REGISTRY NUMBER :: 57564-91-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N4-O7-S

MOLECULAR WEIGHT :: 336.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 umol/plate

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,3847,1986

S-亚硝基谷胱甘肽安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MC0558000

[ 海关编码 ]:
2930909090

S-亚硝基谷胱甘肽合成路线

详细合成路线

S-亚硝基谷胱甘肽上下游产品

S-亚硝基谷胱甘肽上游产品

S-亚硝基谷胱甘肽下游产品

S-亚硝基谷胱甘肽海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

S-亚硝基谷胱甘肽文献

Down regulation of NO signaling in Trypanosoma cruzi upon parasite-extracellular matrix interaction: changes in protein modification by nitrosylation and nitration.

PLoS Negl. Trop. Dis. 9 , e0003683, (2015)

Adhesion of the Trypanosoma cruzi trypomastigotes, the causative agent of Chagas' disease in humans, to components of the extracellular matrix (ECM) is an important step in host cell invasion. The sig...

Lipopolysaccharides Promote S-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophages in Vivo.

J. Biol. Chem. 290 , 19011-7, (2015)

LKB1 (liver kinase B1) plays important roles in tumor suppression, energy metabolism, and, recently, in innate immune responses. However, how LKB1 is regulated under physiological or pathological cond...

S-nitrosylation triggers ABI5 degradation to promote seed germination and seedling growth.

Nat. Commun. 6 , 8669, (2015)

Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regula...

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