20-羟基蜕皮甾酮

20-羟基蜕皮甾酮用途

Crustecdysone (20-Hydroxyecdysone) 是一种天然存在的蜕皮激素,源于露水草 Cyanotis arachnoides C.B.Clarke, 可控制节肢动物的蜕皮和变态,它通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶 (Caspase) 活性并诱导自噬 (autophagy)。Crustecdysone 在心血管系统中具有调节或保护作用。

20-羟基蜕皮甾酮名称

[ CAS 号 ]:
5289-74-7

[ 中文名 ]:
蜕皮激素

[ 英文名 ]:
Hydroxyecdysone

[中文别名 ]:

[英文别名 ]:

CRUSTECDYSONE
20-hydroxyecdysone
MFCD00036740
β-ecdysone
Hydroxyecdysone
b-Ecdysone
Isoinokosterone
Commisterone
Ecdysterone

20-羟基蜕皮甾酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

信号通路 >> 自噬 >> 自噬

[参考文献]

[1]. Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9.

[2]. Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.

20-羟基蜕皮甾酮物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
702.1±60.0 °C at 760 mmHg

[ 熔点 ]:
242-244 °C

[ 分子式 ]:
C₂₇H₄₄O₇

[ 分子量 ]:
480.634

[ 闪点 ]:
392.4±29.4 °C

[ 精确质量 ]:
480.308716

[ PSA ]:
138.45000

[ LogP ]:
-0.53

[ 外观性状 ]:
淡黄色黄色细粉末

[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C

[ 折射率 ]:
1.597

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
alcohol: soluble

20-羟基蜕皮甾酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ8060000

CHEMICAL NAME :: 5-beta-Cholest-7-en-6-one, 2-beta,3-beta,14,20,22,25-hexahydroxy-, (22R)-

CAS REGISTRY NUMBER :: 5289-74-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C27-H44-O7

MOLECULAR WEIGHT :: 480.71

WISWESSER LINE NOTATION :: L E5 B666 LV JUTJ A1 E1 FXQ1&YQ2XQ1&1 IQ OQ PQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 350 ug/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 100 nmol/L

REFERENCE :: ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72. Volume(issue)/page/year: 41,183,1971

20-羟基蜕皮甾酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
FZ8060000

[ 包装等级 ]:
II; III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2937290090

20-羟基蜕皮甾酮制备

可从昆虫、甲壳类动物和植物中分离出这类生理活性物质。已能人工化学合成，但由于化学结构复杂，合成工序很多。

20-羟基蜕皮甾酮海关

[ 海关编码 ]: 2937290090

20-羟基蜕皮甾酮文献

Functions of nuclear receptor HR3 during larval-pupal molting in Leptinotarsa decemlineata (Say) revealed by in vivo RNA interference.

Insect Biochem. Mol. Biol. 63 , 23-33, (2015)

Our previous results revealed that RNA interference-aided knockdown of Leptinotarsa decemlineata FTZ-F1 (LdFTZ-F1) reduced 20E titer, and impaired pupation. In this study, we characterized a putative ...

Identification of two juvenile hormone inducible transcription factors from the silkworm, Bombyx mori.

J. Insect Physiol. 80 , 31-41, (2015)

Juvenile hormone (JH) regulates many physiological processes in insects. However, the signal cascades in which JH is active have not yet been fully elucidated, particularly in comparison to another ma...

A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila.

Nucleic Acids Res. 42(16) , 10409-24, (2014)

The early genes are a key group of ecdysone targets that function at the top of the signaling hierarchy. In the presence of ecdysone, early genes exhibit a highly characteristic rapid and powerful ind...

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