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花生四烯酸

花生四烯酸用途

【用途一】
合成前列腺素的原料。
调节人体细胞膜的通透性。
对婴幼儿的大脑、神经发育，视神经系统的发育十分重要。
在治疗冠心病、糖尿病及预防脑血管等疾病方面也起着重要作用。
【用途二】
营养强化剂。

花生四烯酸名称

[ CAS 号 ]:
506-32-1

[ 中文名 ]:
花生四烯酸

[ 英文名 ]:
Arachidonic acid

[中文别名 ]:

[英文别名 ]:

(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid
AA
Immunocytophyte
eicosatetraenoic acid
MFCD00004417
PUFA 20:4n-6
ARACHIDONIC ACID(RG)
5,8,11,14-Icosatetraenoic Acid
Arachidonic acid
Hydrazinecarboselenoamide

花生四烯酸生物活性

[ 描述 ]:

Arachidonic acid 是必需脂肪酸,是生物膜的主要成分。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 炎症/免疫

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

花生四烯酸(ARA)转化为各种脂质介质,如前列腺素E2(PGE2),参与类风湿性关节炎(RA)的发展[1]。

[参考文献]

[1]. Tateishi N, et al. Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. Lipids Health Dis. 2015 Jan 16;14:3.

[相关活性小分子]

花生四烯酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
407.5±0.0 °C at 760 mmHg

[ 熔点 ]:
−49 °C(lit.)

[ 分子式 ]:
C₂₀H₃₂O₂

[ 分子量 ]:
304.467

[ 闪点 ]:
336.3±18.0 °C

[ 精确质量 ]:
304.240234

[ PSA ]:
37.30000

[ LogP ]:
6.91

[ 外观性状 ]:
略黄色自由流动液体

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.501

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
PRACTICALLY INSOLUBLE

花生四烯酸MSDS

详细MSDS(安全技术说明书)

花生四烯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE6675000

CHEMICAL NAME :: Arachidonic acid

CAS REGISTRY NUMBER :: 506-32-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H32-O2

MOLECULAR WEIGHT :: 304.52

WISWESSER LINE NOTATION :: QV4U3U3U3U6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 320 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 27,95,1986 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,481,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1132 No. of Facilities: 27 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 79 (estimated) No. of Female Employees: 60 (estimated)

花生四烯酸安全信息

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F

[ 风险声明 (欧洲) ]:
R19

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CE6675000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2916190090

花生四烯酸上下游产品

花生四烯酸上游产品

花生四烯酸下游产品

花生四烯酸制备

1. 植物来源有十字花科植物荒野独行莱，北美独行菜油等，还存在于人体的肝、脑、特定组织、动物脂肪中，人脂肪中含量较少，是构成动物磷脂的重要组成部分，可以化学合成。

2. 从炔丙氧基四氢吡喃和1-庚炔制备。

花生四烯酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

花生四烯酸文献

Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells.

J. Nutr. Biochem. 25(12) , 1254-62, (2014)

The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients an...

Cryopreservation prevents iron-initiated highly unsaturated fatty acid loss during storage of human blood on chromatography paper at -20°C.

J. Nutr. 145(3) , 654-60, (2015)

Fingertip prick whole blood collection on chromatography paper is amenable to high-throughput fatty acid (FA) profiling for large clinical and field studies. However, sample storage is problematic bec...

Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models.

Clin. Exp. Allergy 44(12) , 1515-24, (2014)

Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureu...

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