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花生酸

花生酸用途

Arachidonic acid (Icosanoic acid) 是一种长链脂肪酸,存在于所有哺乳动物细胞中,通常酯化为膜磷脂,是人体组织中最丰富的多不饱和脂肪酸之一。

花生酸名称

[ CAS 号 ]:
506-30-9

[ 中文名 ]:
花生酸

[ 英文名 ]:
Arachidic acid

[中文别名 ]:

[英文别名 ]:

Eicosanoic acid
Arachidic acid
Icosanoic acid
N-EICOSANOIC ACID
Arachic acid
MFCD00002755
EINECS 208-031-3

花生酸生物活性

[ 描述 ]:

Arachidonic acid (Icosanoic acid) 是一种长链脂肪酸,存在于所有哺乳动物细胞中,通常酯化为膜磷脂,是人体组织中最丰富的多不饱和脂肪酸之一。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Koppová I, et al. Analysis of fatty acid composition of anaerobic rumen fungi. Folia Microbiol (Praha). 2008;53(3):217-20.

[2]. Martin SA, et al. The discovery and early structural studies of arachidonic acid. J Lipid Res. 2016 Jul;57(7):1126-32.

花生酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
376.4±5.0 °C at 760 mmHg

[ 熔点 ]:
74-76 °C(lit.)

[ 分子式 ]:
C₂₀H₄₀O₂

[ 分子量 ]:
312.530

[ 闪点 ]:
169.7±12.5 °C

[ 精确质量 ]:
312.302826

[ PSA ]:
37.30000

[ LogP ]:
9.28

[ 外观性状 ]:
淡黄色片

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.457

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
practically insoluble

花生酸MSDS

花生酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3780000

CHEMICAL NAME :: Eicosanoic acid

CAS REGISTRY NUMBER :: 506-30-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H40-O2

MOLECULAR WEIGHT :: 312.60

WISWESSER LINE NOTATION :: QV19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2641 No. of Facilities: 858 (estimated) No. of Industries: 13 No. of Occupations: 24 No. of Employees: 12080 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2641 No. of Facilities: 138 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 3362 (estimated) No. of Female Employees: 1859 (estimated)

花生酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
JX3780000

[ 海关编码 ]:
2915900090

花生酸合成路线

花生酸制备

1. 可由花生油水解和分离而得。也可由氧化石蜡而得。

2. 烟草：FC，9，15， 41；BU，9。

3. 从乙醇中得结晶。

花生酸海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

花生酸文献

Direct detection of free fatty acids in edible oils using supercritical fluid chromatography coupled with mass spectrometry.

Food Chem. 170 , 463-9, (2014)

Determination of free fatty acids (FFAs) in food products is of enormous interest mainly because they are related to the quality and authenticity of the oils. In this study, supercritical fluid chroma...

Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.

Clin. Chim. Acta 438 , 126-34, (2014)

As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This stud...

Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species.

Lipids 49(6) , 505-15, (2014)

Hepatic lipase (HL) and endothelial lipase (EL) share overlapping and complementary roles in lipoprotein metabolism. The deletion of HL and EL alleles in mice raises plasma total cholesterol and phosp...

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花生酸