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竹桃霉素

竹桃霉素用途

Oleandomycin 是一种大环内酯类抗生素,在结构上与红霉素相关。其抗菌谱与红霉素相似。

竹桃霉素名称

[ CAS 号 ]:
3922-90-5

[ 中文名 ]:
竹桃霉素

[ 英文名 ]:
Oleandomycin

[英文别名 ]:

Oleandomycin
Oleamidopropyl dimethyl glycine
N-Oleoylamidopropyl-N,N-dimethylbetaine
Oleamidopropyl betaine

竹桃霉素生物活性

[ 描述 ]:

Oleandomycin 是一种大环内酯类抗生素,在结构上与红霉素相关。其抗菌谱与红霉素相似。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Vilches C, et al. Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus. J Bacteriol. 1992 Jan;174(1):161-5.

竹桃霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
802.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₅H₆₁NO₁₂

[ 分子量 ]:
687.858

[ 闪点 ]:
439.2±34.3 °C

[ 精确质量 ]:
687.419373

[ PSA ]:
165.98000

[ LogP ]:
1.23

[ 蒸汽压 ]:
0.0±6.4 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
2-8℃

竹桃霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RJ9220000

CHEMICAL NAME :: Oleandomycin

CAS REGISTRY NUMBER :: 3922-90-5

LAST UPDATED :: 199012

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C35-H61-N-O12

MOLECULAR WEIGHT :: 687.97

WISWESSER LINE NOTATION :: T-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year: 39,259,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,475,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2343 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :: HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

竹桃霉素

竹桃霉素用途

竹桃霉素名称

竹桃霉素生物活性

竹桃霉素物理化学性质

竹桃霉素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

竹桃霉素合成路线

详细合成路线

竹桃霉素上下游产品

竹桃霉素上游产品

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