5-氟尿嘧啶核苷

5-氟尿嘧啶核苷用途

5-Fluorouridine 是 5-fluorouracil 的代谢物,具有抗癌活性。5-Fluorouridine 能抑制人结肠癌细胞 rRNA 的合成。5-Fluorouridine 对 L1210 细胞的生长具有细胞毒性作用,其作用的 IC50 值为 2 nM。

5-氟尿嘧啶核苷名称

[ CAS 号 ]:
316-46-1

[ 中文名 ]:
5-氟尿嘧啶核苷

[ 英文名 ]:
5-Fluorouridine

[中文别名 ]:

5-氟尿嘧啶1Β-D-呋喃核糖苷

[英文别名 ]:

L-5-Fluorouridine
FURD
5-fluoro-uridine
FUR
5-FLUOROIDINE
5-fur
5-Fluor-uridin
EINECS 206-260-3
MFCD00036832
5-Fluorouridine

5-氟尿嘧啶核苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Wu FL , et al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16.

[2]. Hu N, et al. Strengthening Gastric Cancer Therapy by Trastuzumab-Conjugated Nanoparticles with Simultaneous Encapsulation of Anti-MiR-21 and 5-Fluorouridine. Cell Physiol Biochem. 2017;44(6):2158-2173.

[3]. Glazer RI, et al. Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture. Mol Pharmacol. 1982 Mar;21(2):468-73.

[4]. Kanzawa F, et al. Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems. Eur J Cancer. 1980 Aug;16(8):1087-92.

5-氟尿嘧啶核苷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 熔点 ]:
182-184 °C

[ 分子式 ]:
C₉H₁₁FN₂O₆

[ 分子量 ]:
262.192

[ 精确质量 ]:
262.060120

[ PSA ]:
124.78000

[ LogP ]:
-1.34

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.641

[ 储存条件 ]:
室温，密封，干燥

[ 水溶解性 ]:
soluble

5-氟尿嘧啶核苷MSDS

5-氟尿嘧啶核苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU8050000

CHEMICAL NAME :: Uridine, 5-fluoro-

CAS REGISTRY NUMBER :: 316-46-1

BEILSTEIN REFERENCE NO. :: 0033662

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-F-N2-O6

MOLECULAR WEIGHT :: 262.22

WISWESSER LINE NOTATION :: T6NVMVJ EF A- ET5OTJ B1Q CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 384 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 900 nmol/L

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

5-氟尿嘧啶核苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YU8050000

[ 海关编码 ]:
2942000000

5-氟尿嘧啶核苷合成路线

5-氟尿嘧啶核苷上下游产品

5-氟尿嘧啶核苷上游产品

5-氟尿嘧啶核苷下游产品

5-氟尿嘧啶核苷海关

[ 海关编码 ]: 2942000000

5-氟尿嘧啶核苷文献

Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.

J. Pharm. Biomed. Anal. 110 , 58-66, (2015)

5-Fluorouracil (5-FU) and its oral prodrug capecitabine are among the most widely used chemotherapeutics. For cytotoxic activity, 5-FU requires cellular uptake and intracellular metabolic activation. ...

N4-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine—New drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate)

Bioorg. Med. Chem. 19(11) , 3520-6, (2011)

New cytostatic antimetabolite-bisphosphonates.

Evidence for Transcriptional Activity in the Syncytiotrophoblast of the Human Placenta

Placenta 30(4) , 329-34, (2009)

The aim was to test for evidence of transcriptional activity within the nuclei of the syncytiotrophoblast of the human placenta. The syncytiotrophoblast forms the epithelial covering of the villous tr...

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